Abstract: The interconnection of technical devices by new technology has to be based on the requirements needed to fulfill legal compliance. This interconnection and the increasing complexity coming with it require the knowledge of interrelations within an organization in order to progress towards an integrated organization. In this paper we intend to provide an overview on what kind of general challenges are up-coming and what kind of organizational challenges we have to solve in companies to fulfill the requirements of industrial projects which have to consider both functional safety and cybersecurity. The domain of functional safety and the expanding domain of cybersecurity both come with a high complexity and with their own grading and certification schemes, defense-in-depth architectures, comprehensive sets of standards and guidelines which are endorsed by specialists familiar with one of these domains. Accordingly, agreeing on effective and affordable approaches to handle the safety & security interface are still ongoing, both for generic solutions and for business-domain specific regulation. Part of this work results are from an ongoing exchange in the Sino-German Industry 4.0 / Intelligent Manufacturing Standardization Sub-Working Group that includes a track on functional safety and a track on cybersecurity, additionally to further tracks relevant to cyber physical systems, e.g. on reference architecture models, preventive maintenance, edge and fog computing.